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Biography

SNZ

Dr Serena Nik-Zainal

Research Profile

 

 

 

 

 

Biography

Serena is a CRUK Advanced Clinician Scientist and an Honorary Consultant in Clinical Genetics. Serena qualified in medicine from the University of Cambridge in 2000 on a scholarship from Petronas, Malaysia. She undertook a PhD at the Wellcome Sanger Institute (WSI) in 2009 exploring breast cancer using whole genome sequencing (WGS). She demonstrated how detailed downstream analyses of all mutations present in WGS breast cancers could reveal mutation signatures, imprints left by mutagenic processes that have occurred through cancer development. She also identified a novel phenomenon of localised hypermutation termed “kataegis”. 

Serena was awarded a Wellcome Trust Intermediate Clinical Fellowship in 2013. She joined the Sanger Institute faculty team in 2014 and continued to develop particular expertise in the analysis and interpretation of WGS tumours. Apart from using computational approaches, she also studies mutational signatures experimentally using cell-based model systems. She was awarded a CRUK Advanced Clinician Scientist Fellowship in 2017 and moved to the University of Cambridge in order to accelerate the translation of her genomics expertise towards clinical applications and to further her work into the physiological mechanisms underpinning mutagenesis.

Cover of Cell in 2012 highlighting the showers of mutagenesis that can occur in human cancers, called kataegis.