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Analysis of the pathogenesis and therapy of BRCA2-mutant cancers using genetics and molecular cell biology. A. Chromosomal instability evoked by BRCA2 inactivation provides the first insights into its role in mitotic recombination (see Patel et al Mol Cell (1998)). B. Aneuploidy in BRCA2-deficient cells associated with defects in the completion of mitotic cell division (see Daniels et al Science (2004), Lee et al Oncogene (2011)). C. Progression of pancreatic neoplasia (top panel) and therapeutic responsiveness to Olaparib (bottom panel) revealed in a model for tissue-specific carcinogenesis associated with BRCA2 inactivation summarized in D (see Skoulidis et al Cancer Cell (2010)).

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