skip to primary navigationskip to content
 

Organoid cultures – a new tool in the study of a deadly solid tumour with very poor prognosis

last modified Sep 21, 2018 11:24 AM

Models of cancer are needed to test drugs and understand how they develop. Few models exist for cancer of the gullet (oesophagus). This recent publication from the Fitzgerald lab, selected as an Editors' Highlight by Nature Communications for its Stem cell and Disease as well as Genomes and Epigenomes portals is a collaborative study between the Sanger Institute Nature Communications logo(Mathew Garnet) and the MRC Cancer Unit (Rebecca Fitzgerald) and is based on the establishment of a panel of organoid cultures derived from Oesophageal Adenocarcinoma. These 3D cultures were established from patients undergoing extensive molecular characterisation as part of the International Cancer Genome Consortium. The authors were able to show that these organoids faithfully recapitulated the morphological, functional and genetic features of tumours and the cultures yielded interesting data on tumour evolution and susceptibility to chemotherapy and molecularly targeted agents. This research provides the community with a powerful translational tool for this very poor prognosis disease.

 

organoids

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.

The study entitled Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics by Xiaodun Li et al. has been published in Nature Communications volume 9, Article number: 2983 (2018) on 30 July, 2018.