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MRC Cancer Unit

 
Read more at: Genome sequencing accelerates cancer detection

Genome sequencing accelerates cancer detection

8 September 2020

Barrett's oesophagus and oesophageal cancer are diagnosed using biopsies, which look for signs of dysplasia. Between one and five people in every 100 with Barrett's oesophagus will go on to develop oesophageal cancer in their life-time, but as this type of cancer can be difficult to treat, particularly if not caught early...


Read more at: MRC Cancer Unit to participate in the European Project Evomet, which will train future leaders in metastasis research

MRC Cancer Unit to participate in the European Project Evomet, which will train future leaders in metastasis research

4 September 2020

The goal is to train 15 young researchers in the understanding of metastatic processes and their evolution, with the aim to identify therapeutic solutions. The Evomet consortium is formed by 13 institutions, which include several of the best academic, clinical and industrial centres working in cancer research and...


Read more at: A kinase-independent function for AURORA-A in DNA replication initiation

A kinase-independent function for AURORA-A in DNA replication initiation

4 August 2020

The Aur ora protein kinase, AURKA, is overexpressed in many human cancers, which promotes carcinogenesis by perturbing mitotic cell division. Work by Guarino-Almeida et al. in Ashok Venkitaraman’s group now identifies a novel biological function for AURKA in the initiation of DNA replication, which, surprisingly, is...


Read more at: ‘Sponge on a string’ test to transform oesophageal cancer diagnosis

‘Sponge on a string’ test to transform oesophageal cancer diagnosis

31 July 2020

The trial results for the Cytosponge test, developed over many years by Rebecca Fitzgerald’s group at the MRC CU in collaboration with numerous collaborators, published in The Lancet today , mark a ‘game changer’ moment in the journey of the early detection device and test towards patient care. The results published today...


Read more at: Dr Serena Nik-Zainal elected as EMBO Member -July 2020

Dr Serena Nik-Zainal elected as EMBO Member -July 2020

6 July 2020

Many congratulations to Dr Se rena Nik-Zainal for being elected as an EMBO member! EMBO has bestowed upon 63 leading scientists, 8 of whom are from Cambridge, the lifetime honour of EMBO Membership in recognition of their remarkable achievements in the life sciences, it was announced on the 7th of July. Serena thus joins...


Read more at: PhD student Annie Howitt becomes runners-up at FameLab 2020

PhD student Annie Howitt becomes runners-up at FameLab 2020

6 July 2020

On the 3nd of June Annie Howitt (PhD student) took part in the Famelab 2020 UK final. Fame Lab is an international science communication competition, in which contestants have 3 minutes to give a scientific talk, using just their voice and props to impress the judges. The competition ran a little differently this year...


Read more at: Why the microenvironment matters

Why the microenvironment matters

8 June 2020

Single cell RNA-sequencing reveals a dynamic stromal niche that supports t umour growth Cancer cells are surrounded by a diverse range of “normal cells” known as the stroma. The stroma includes immune cells, endothelial cells, fibroblasts and the extracellular matrix scaffold they produce. Together cancer cells and stroma...


Read more at: The expansion of ‘mutant’ cells that could lead to cancer is often restricted by their neighbours

The expansion of ‘mutant’ cells that could lead to cancer is often restricted by their neighbours

8 June 2020

Spatial competition shapes the dynamic mutational landscape of normal oesophageal epithelium Some DNA mutations, particularly those affecting known ‘cancer genes’ such as TP53 and NOTCH1, confer a competitive advantage on cells that acquire them. This allows these mutant clones to expand more rapidly than normal cells and...


Read more at: Contributing to the national Covid-19 response

Contributing to the national Covid-19 response

4 May 2020

At a time when the scientific community worldwide rallies around to fight back this deadly disease, researchers and staff at the MRC Cancer Unit and the Hutchison/MRC Research Centre continue to play their part. Several of our post-docs have volunteered their expertise at the newly set up University-AZ-GSK testing centres...


Read more at: Global Shakers in the Fight to Cure Cancer, 2020

Global Shakers in the Fight to Cure Cancer, 2020

4 May 2020

Congratulations to Professor Rebecca Fitzgerald and Dr Serena Nik-Zainal for featuring in the list of 15 ‘ Shakers in the Fight to Cure Cancer ’ - a distinguished list of individuals from around the world dedicated to curing cancer in areas from genomics to artificial intelligence. (February 2020)