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A kinase-independent function for AURORA-A in DNA replication initiation

last modified Aug 04, 2020 10:06 AM

The Aurora protein kinase, AURKA, is overexpressed in many human cancers, which promotes carcinogenesis by perturbing mitotic cell division. Work by Guarino-Almeida et al. in Ashok Venkitaraman’s group now identifies a novel biological function for AURKA in the initiation of DNA replication, which, surprisingly, is independent of its catalytic activity. They show that this new AURKA function can be targeted by an emerging class of chemical inhibitors that modulate the conformation and protein-protein interactions of AURKA, opening fresh avenues for cancer therapy.

The study entitled A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation was published in Nucleic Acid Research on 11 July, 2020