Mutations of Krebs cycle enzymes (A) and of components of oxidative phosphorylation (B) are associated to human cancers. The figure has been adapted from Gaude and Frezza, Cancer and Metabolism, 2014.

Schematic representation of the three major components of the metabolic rewiring observed in cancer cells. Mitochondrial metabolism, aerobic glycolysis, and fatty acid metabolism are deeply intertwined and cooperate to fulfil the increased biosynthetic demands of cancer cells. Full circles over the enzymatic reactions indicate that the reaction is controlled by oncogenes or tumour suppressor. The figure is adapted from Sciacovelli et al, Methods in Enzymology, 2013, where you can also find more details about the individual reactions.

BEST3 Study design summary