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CLICK HERE FOR A HIGH RESOLUTION IMAGE. Images taken with an endoscope: (A left picture) White light image, (A middle picture) Imaging fluorescence at 490-560 nm pre application of WGA, (A right picture). Imaging fluorescence at 490-560 nm post application of WGA-Alexa Fluor™ 488. The areas of low WGA binding appear purple. The dashed white line is placed longitudinally along the posterior wall of the esophagus to facilitate orientation between different images and the numbers 7, 8, and 9 refer to the y-coordinates on the reference grid in (B). Grid displaying the pathological diagnostic map (color coded with dark color representing a worsening grade of dysplasia) of each block made from the resection specimen. This same grid can be compared with the endoscopic and IVIS fluorescence images in A (right picture) and D. The dashed line represents the longitudinal axis along the posterior wall of the esophagus.The same specimen after being opened longitudinally along the anterior border of the esophagus is displayed with the overlying grid from B. WGA fluorescence signal from the esophageal specimen taken with the IVIS 200 camera. The pink arrow marks an area of artefact from exposed submucosal tissue and the blue arrow indicates the site of a previous endoscopic mucosal resection (surrounded by grey box).

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