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CRUK CI Lecture Theatre seminars

Thu 26 Sep 13:00: TET-family dioxygenases, immune responses and cancer

From CRUK CI Lecture Theatre. Published on Aug 22, 2019.

TET-family dioxygenases, immune responses and cancer

In 2009, our lab reported that enzymes of the TET (Ten-Eleven Translocation) family were a new class of epigenetic regulators that altered the modification status of cytosine bases in DNA . The three mammalian TET enzymes – TET1 , TET2 and TET3 – successively oxidize the methyl group of 5-methylcytosine (5mC) to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). These modified cytosine bases (together termed oxidized methylcytosines, oxi-mC) facilitate DNA demethylation and are also novel epigenetic marks. DNA methylation has long been linked to developmental processes and to oncogenesis; similarly TET proteins, which alter DNA modification status, are implicated in numerous biological processes, including cell lineage specification, embryonic development, immune and neuronal function, “stemness” somatic cell reprogramming and cancer. I will discuss the relation between TET activity, DNA modification status and oncogenesis in several model systems with TET loss-of-function.

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Fri 11 Oct 13:00: Title to be confirmed ***Please note this seminar is on a Friday***

From CRUK CI Lecture Theatre. Published on Jan 09, 2019.

Title to be confirmed

Abstract not available

***Please note this seminar is on a Friday***

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Thu 31 Oct 13:00: Title to be confirmed

From CRUK CI Lecture Theatre. Published on Sep 25, 2018.

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Abstract not available

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Thu 21 Nov 13:00: Title to be confirmed

From CRUK CI Lecture Theatre. Published on Oct 24, 2018.

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Abstract not available

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Thu 23 Jan 13:00: Title to be confirmed

From CRUK CI Lecture Theatre. Published on May 09, 2019.

Title to be confirmed

Abstract not available

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