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4genesignature.jpg

Kaplan–Meier plots of survival comparing outcomes for patients with 0 of 4, 1–2 of 4, and 3–4 of 4 genes dysregulated for (A) the complete external validation dataset (_2 LR, 13.582; 2 df; P _ 0.001), (B) external validation set patients who were chemotherapy-naive (_2 LR, 4.323; 2 df; P _ .038), and (C) external validation dataset patients who had received neoadjuvant chemotherapy (_2 LR, 5.013; 2 df; P _ .025). Notches represent censored data; P values were calculated using the log-rank (Mantel–Cox) test.