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brac2 av3

A. Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombination enzyme (see Rajendra & Venkitaraman, Nuc Acids Res (2010)). B. A schematic illustration summarizing the functions of BRCA2 in the assembly of RAD51 filaments on damaged DNA (see Venkitaraman, Ann Rev Pathol (2009)). C. BRC repeats delay dsDNA capture (top panel) coincident with joint molecule formation (bottom panel) in a reconstituted RAD51-mediated DNA recombination reaction (see Shivji et al Proc Nat Acad Sci USA (2009)). D. Opposing actions of the BRC repeats stabilize ssDNA-RAD51 binding whilst inhibiting dsDNA-RAD51 capture to coordinate RAD51-mediated strand exchange (see Shivji et al Proc Nat Acad Sci USA (2009)).
brac2 av3
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