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Journal Club

Below is a list of past and upcoming papers discussed during the cancer metabolism journal club appointments. If you would like to join the journal club please contact .

2016

26th January       

Edoardo Gaude

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

 

9th February

Emma Kerr

NRF2 regulates serine biosynthesis in non–small cell lung cancer

 

23rd February

Inge Wortel

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

 

8th March

Isaac Johnson

Spatial colocalization and functional link of purinosomes with mitochondria

 

22nd March

Frances Turrell

High-fat diet enhances stemness andtumorigenicity of intestinal progenitors

 

5th April

Sofia Costa

Hypoxia as a therapy for mitochondrial disease

 

19th April

Edoardo Gaude

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

 

3rd May

Vincent Zecchini

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

 

17th May

Inge Wortell

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

 

14th June

Marco Sciacovelli

 

 

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

28th June

Ashley Ferguson

 

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

 

 

2015 

13th January

Frances Turrell

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

 

27th January

Sofia Costa

 

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

 

17th February

Eva Maria Surman

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

 

3rd March

Petros Tyrakis

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

 

17th March

Edoardo Gaude

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.

 

28th April

Vincent Zecchini

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

 

26th May

Emma Kerr

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in-vivo

 

23rd June

Frances Turrell

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.

 

30th June

Isaac Johnson

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence.

 

28th July

Marco Sciacovelli

 

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.

 

8th September

Petros Tyrakis

Hypoxia Induces Production of L-2-Hydroxyglutarate

 

22nd September  Eva-Marie Surmann

Metabolic competition in the tumor microenvironment is a driver of cancer progression

 

27th October

Sofia Costa

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

 

24th November

Sofia Costa

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

 

 

2014

14th January

Petros Tyrakis

 

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

 

4th February

Susana Barros

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

17th February

Eva-Maria Surmann

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

4th March

Isaac Johnson

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage
by inhibiting mitochondrial glutamine metabolism

18th March

Edoardo Gaude

Nonenzymatic formation of succinate in mitochondria under oxidative stress

1st April

Emma Kerr

Tumour-associated mutant p53 drives the Warburg effect

15th April

Marco Sciacovelli

Metabolic control of YAP and TAZ by the mevalonate pathway

29th April

Emanuel Goncalves

Regulation of yeast central metabolism by enzyme phosphorylation

20th May

Isaac Johnson

Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation

17th June

Ana Sofia Henriques da Costa

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

1st July

Frances Turrell

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

22nd July

Petros Tyrakis

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

2nd September

Eva-Maria Surmann

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

16th September

Edoardo Gaude

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

7th October

Vincent Zecchini

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

21st October

Postponed

11th November

Isaac Johnson

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

25th November Emma Kerr
TBA

16th December

Marco Sciacovelli


A Positive Feedback Loop between Mesenchymal-like
Cancer Cells and Macrophages Is Essential
to Breast Cancer Metastasis