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Current Vacancies

Research Associate (Fixed Term)

Applications are invited for a Research Associate  to join Dr Carla Martins' research group at the MRC Cancer Unit, which is focused on "Modelling Tumour Development and Therapy".

The post-holder will be involved in a project aimed at characterizing the impact of Kras copy number changes on lung tumour therapy. This work will involve a wide range of molecular biology techniques and will combine in vitro and in vivo cancer models. We are seeking applicants with a PhD in Cancer Biology or closely related field and extensive experience in molecular biology (cloning, DNA, RNA and protein analysis), tissue culture and cancer metabolism. A good track record of peer-reviewed publications is desirable, as is experience in mouse modeling and analysis of large-scale data sets (e.g. RNAseq data). Candidates should be able to demonstrate abstract thinking as well as the potential to develop and pursue scientific projects in the field of cancer biology. He/she is expected to undertake cutting edge research and to act independently to plan experiments, solve problems and learn and apply new techniques whenever required.

For queries regarding this post please contact admin@mrc-cu.cam.ac.uk

Fixed-term: The funds for this post are available until 31 December 2018 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. The University values diversity and is committed to equality of opportunity.

The closing date for applications is Sunday 11th December 2016.

Interviews are likely to take place between the 13th and 16th December 2016.

To apply online for this vacancy please visit the link below:

http://www.jobs.cam.ac.uk/job/12126/

 

 

Clinical Research Associate (Fixed Term)

Applications are invited to apply for a Clinical Research Associate position within an established translational research programme headed by Professor Rebecca Fitzgerald and Dr Massimiliano di Pietro, focusing on novel endoscopic and non-endoscopic tools for the early detection of Barrett's related neoplastic. For more information visit http://www.mrc-cu.cam.ac.uk/research/rebecca-fitzgerald

Applicants need to be clinically qualified with full GMC registration and an Honorary Clinical Contract in place by the start of the appointment. Competence in performing upper GI endoscopy is essential with experience in advanced endoscopic imaging and clinical research advantageous. The post holder will have excellent communication skills (written and oral) and be highly motivated. It may be possible for the candidate to undertake training in advanced endoscopic therapy modalities for Barrett's related neoplasia (including EMR and RFA), in line with the new British Society of Gastroenterology Guidelines for the management of Barrett's oesophagus.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check. This appointment also requires an Honorary Clinical Contract.

To apply online for this vacancy please visit the link below:

http://www.jobs.cam.ac.uk/job/11302

 


Research Governance and Integrity Coordinator

The Hutchison/MRC Research Centre is an established centre for translational cancer research, housing both the MRC Cancer Unit and components of the Department of Oncology (departments within the University of Cambridge) (www.hutchison-mrc.cam.ac.uk).

The position of Research Governance and Integrity Coordinator is jointly funded by the Medical Research Council and the University of Cambridge, and is held within the MRC Cancer Unit, based within the research centre. The post holder's main responsibility will be to ensure research centre wide compliance with regard to research governance legislation and to assist with practical matters relating to ethics applications, databases and reports.

Educated to degree level, or with equivalent experience from working in a similar environment, the post holder must be familiar with the relevant legal and regulatory framework related to research governance and have strong administrative, organisation and time management skills. Excellent communication skills are also essential.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy please visit the link below:

http://www.jobs.cam.ac.uk/job/11359/

 


We have PhD opportunities for entry in October 2017 available in the following areas:

 

MRC DTA PhD Studentship

Determination of clonal ordering and competition in progression from Barrett's to oesophageal adenocarcinoma Professor Rebecca Fitzgerald

The Medical Research Council Cancer Unit at the University of Cambridge is a leading centre for cancer research in the UK.  Our aim is to undertake research into cancer biology that can be translated into clinical practice to improve the diagnosis and treatment of cancers.  The Unit is based within the Hutchison/MRC Research Centre on the Cambridge Biomedical Campus, and possesses excellent research facilities, strong collaborations with clinicians and colleagues in other disciplines, and a vibrant and supportive working environment.

Genetic events driving the progression from pre-malignant to malignant disease are still poorly understood.  Barrett's carcinogenesis is an ideal disease to study cancer evolution since patients are monitored longitudinally and oesophageal samples are readily collected at endoscopy.  Furthermore through the whole genome sequencing efforts of the Fitzgerald laboratory, as part of the International Cancer Genome Consortium (ICGC), we have a growing understanding of the mutations present in different disease stages.  In collaboration with the Sanger, new primary model systems derived from the same patients for which we have sequencing are becoming available.  In this PhD project the candidate will join a large, dynamic multidisciplinary research group comprising computational biologists, postdocs and clinician scientists working on different aspects of the ICGC data with complementary expertise.  This project will examine: a) the significance of the order in which mutations are acquired, and b) the determinants and consequences of clonal competition in driving indolent premalignant disease to become invasive.  To do this the candidate will analyse patient derived genomic data from the ICGC as well as performing experiments using in vitro 2D and 3D model systems including organoids.  They will learn genome editing (CRISPR, Tet-on/off) to develop a range of genetically modified models which can then be assessed for effects on cell behaviour using quantitative assays including confocal microscopy, live-cell imaging and cell based functional assays (proliferation, apoptosis, invasion etc.).  This PhD is an ideal opportunity to develop research skills in translational cancer medicine.

More information about the research undertaken in the Fitzgerald Lab can be found here- www.mrc-cu.cam.ac.uk/research/rebecca-fitzgerald

Successful applicants will be registered with the University of Cambridge.

In addition to our outstanding research environment we offer a competitive stipend of £18,000 pa. Further information regarding eligibility criteria can be found at www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/

We welcome applications from those holding, or expecting to obtain, at least an upper second class degree (or equivalent) in a relevant scientific subject.    

Please direct applications in the following format to studentships@mrc-cu.cam.ac.uk specifying which project area and principal investigator you are interested in working with.

  • A CV, including full details of all University course grades to date.
  • Contact details for two academic or professional referees.
  • A personal statement outlining your interest      in a specific project area, what you hope to achieve from a PhD, and your      research experience to date.

The closing date for applications is 30 November 2016, with interviews expected to take place on 12 December 2016.

Please contact studentships@mrc-cu.cam.ac.uk with any other enquiries concerning studentships or eligibility criteria.

 


MRC DTA PhD Studentship

Dissecting the role of fumarate as an oncometabolite – Dr. Christian Frezza

The Medical Research Council Cancer Unit at the University of Cambridge is a leading centre for cancer research in the UK.  Our aim is to undertake research into cancer biology that can be translated into clinical practice to improve the diagnosis and treatment of cancers.  The Unit is based within the Hutchison/MRC Research Centre on the Cambridge Biomedical Campus, and possesses excellent research facilities, strong collaborations with clinicians and colleagues in other disciplines, and a vibrant and supportive working environment.

Fumarate Hydratase is a mitochondrial enzyme found mutated in hereditary and sporadic forms of cancer.  How the loss of this mitochondrial enzyme leads to tumorigenesis is still an open question.  It has been proposed that fumarate, a metabolite accumulated in FH-deficient cells, might contribute to tumorigenesis of these types of cancer.  We have recently discovered that fumarate can act as an epigenetic modifier, affecting histone and DNA methylation.  However, mechanisms that lead the translocation of fumarate from the mitochondria to the nucleus are still unknown.  This PhD project aims at designing novel tools to investigate the intracellular distribution of fumarate using a combination of state-of-the-art metabolomics and microscopy.  In particular, we want to build a novel fumarate sensor to study intracellular fumarate pools in real time.  The ideal candidate should have experience in cancer biology and cell metabolism.  Expertise in molecular biology and microscopy are distinct advantages.

More information about the research undertaken in the Frezza lab can be found here- www.mrc-cu.cam.ac.uk/research/Christian-frezza-folder

Successful applicants will be registered with the University of Cambridge.

In addition to our outstanding research environment we offer a competitive stipend of £18,000 pa. Further information regarding eligibility criteria can be found at www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/

We welcome applications from those holding, or expecting to obtain, at least an upper second class degree (or equivalent) in a relevant scientific subject.    

Please direct applications in the following format to studentships@mrc-cu.cam.ac.uk specifying which project area and principal investigator you are interested in working with.

  • A CV, including full details of all University course grades to date.
  • Contact details for two academic or professional referees.
  • A personal statement outlining your interest in a specific project area, what you hope to achieve from a PhD, and your      research experience to date.

The closing date for applications is 30 November 2016, with interviews expected to take place on 12 December 2016.

Please contact studentships@mrc-cu.cam.ac.uk with any other enquiries concerning studentships or eligibility criteria.

 


 MRC DTA PhD Studentship

Defining mechanisms of immune dysfunction in the tumour microenvironment – Dr. Jacqueline Shields

The Medical Research Council Cancer Unit at the University of Cambridge is a leading centre for cancer research in the UK.  Our aim is to undertake research into cancer biology that can be translated into clinical practice to improve the diagnosis and treatment of cancers.  The Unit is based within the Hutchison/MRC Research Centre on the Cambridge Biomedical Campus, and possesses excellent research facilities, strong collaborations with clinicians and colleagues in other disciplines, and a vibrant and supportive working environment.

Although tumours frequently contain immune infiltrates, our immune system is often unable to mount an effective anti-tumour response.  Furthermore, rather than clearing the lesion, immune populations frequently promote disease progression and metastasis. Despite these observations, the mechanisms employed by a growing tumour to avoid immune destruction remain unclear.  However, recent evidence indicates that non-cancerous support cells within tumours, referred to as the stroma, may play a role.  The Shields group aims to determine how and when the stroma is able to orchestrate immune dysfunction during tumour evolution, both in the local microenvironment and downstream lymph nodes.  This project will take an innovative approach that integrates bioengineering principles, novel in vitro systems, state-of-the-art imaging techniques and in vivo tumour models.  Our long-term goal is to translate this knowledge into targeted therapeutic platforms capable of restoring the anti-tumour response.

More information about the research undertaken in the Shields lab can be found here- www.mrc-cu.cam.ac.uk/research/Jacqui-Shields-folder

Successful applicants will be registered with the University of Cambridge.

In addition to our outstanding research environment we offer a competitive stipend of £18,000 pa. Further information regarding eligibility criteria can be found at www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/

We welcome applications from those holding, or expecting to obtain, at least an upper second class degree (or equivalent) in a relevant scientific subject.    

Please direct applications in the following format to studentships@mrc-cu.cam.ac.uk specifying which project area and principal investigator you are interested in working with.

  • A CV, including full details of all University course grades to date.
  • Contact details for two academic or professional referees.
  • A personal statement outlining your interest in a specific project area, what you hope to achieve from a PhD, and your      research experience to date.

The closing date for applications is 30 November 2016, with interviews expected to take place on 12 December 2016.

Please contact studentships@mrc-cu.cam.ac.uk with any other enquiries concerning studentships or eligibility criteria.

 


 MRC DTA PhD Studentship

Molecular basis of cancer metastasis Dr. Sakari Vanharanta

The Medical Research Council Cancer Unit at the University of Cambridge is a leading centre for cancer research in the UK.  Our aim is to undertake research into cancer biology that can be translated into clinical practice to improve the diagnosis and treatment of cancers.  The Unit is based within the Hutchison/MRC Research Centre on the Cambridge Biomedical Campus, and possesses excellent research facilities, strong collaborations with clinicians and colleagues in other disciplines, and a vibrant and supportive working environment.

The majority of cancer-related deaths result from the metastatic spread of cancer to secondary organs.  Even though a multitude of metastasis driver genes have been identified, in most cases metastatic cancer remains incurable.  Thus, there is a critical need for a better understanding of genetic cancer cell dependencies.  Our multi-disciplinary approach combines functional genetics, experimental metastasis models, clinical association analysis, high-throughput genomics and bioinformatics in order to identify genetic regulators of metastatic cell states.  The long-term goal is to translate this knowledge into novel prognostic and treatment modalities for metastatic cancer. PhD projects are available on several specific aspects of our general goal.

More information about the research undertaken in the Vanharanta lab can be found here: www.mrc-cu.cam.ac.uk/research/sakari-vanharanta-folder

Successful applicants will be registered with the University of Cambridge.

In addition to our outstanding research environment we offer a competitive stipend of £18,000 pa. Further information regarding eligibility criteria can be found at www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/

We welcome applications from those holding, or expecting to obtain, at least an upper second class degree (or equivalent) in a relevant scientific subject.    

Please direct applications in the following format to studentships@mrc-cu.cam.ac.uk specifying which project area and principal investigator you are interested in working with.

  • A CV, including full details of all University course grades to date.
  • Contact details for two academic or professional referees.
  • A personal statement outlining your interest in a specific project area, what you hope to achieve from a PhD, and your      research experience to date.

The closing date for applications is 30 November 2016, with interviews expected to take place on 12 December 2016.

Please contact studentships@mrc-cu.cam.ac.uk with any other enquiries concerning studentships or eligibility criteria.

 


Goods-In/Laboratory Porter and Goods-In/Laboratory Support 

 We are recruiting two full time posts, one Goods-In Clerk/Laboratory Porter for the MRC Cancer Unit (MRC CU) and one Goods-In Clerk/Laboratory Support Post for the MRC Mitochondrial Unit (MRC MBU).

The MRC CU post holder will act as a laboratory porter in the Hutchison/MRC Research Centre (HMRC) for 50% of the time.  This is a diverse role, which includes the distribution of incoming and outgoing goods, liquid nitrogen, gas cylinders, dry ice, waste management and general custodial duties. The role will be a back up to the joint Goods-in function based in the adjacent Wellcome Trust/MRC Building. The Goods-in service for the Wellcome Trust/MRC Building supports the Cambridge Institute for Medical Research (CIMR) and the Mitochondrial Biology Unit (MRC MBU) in that building, and also the MRC Cancer Unit and Cambridge University Department of Oncology based in the adjacent HMRC.

Goods-in support will involve accepting deliveries, checking their contents and receipting goods using the University financial system as part of a team of three including staff from the CIMR and the MRC-MBU. The role holders will also be required to organise returns, deal with discrepancies and be responsible for maintaining central supplies of certain items used for research purposes. These posts will manage the daily supply of items from the stores to the scientists in the HMRC.

The MRC MBU post holder will carry out similar duties to the above except that 70% of the role will be carrying out the Goods-In function and the remainder providing support for the MRC MBU.

Good interpersonal skills, clear communication and effective team working are essential, as is an organised and common-sense approach. Previous experience of working in a similar environment is desirable. Applicants must be numerate and literate and have experience of using email and spreadsheets.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy, please visit http://www.jobs.cam.ac.uk/job/11700/.

The closing date for applications is Thursday 20th October 2016.

Interviews are likely to be held on Wednesday 26th October 2016.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SK10339 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.