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'RASA2 is a Novel Tumour Suppressor in Melanoma'

When Dec 18, 2015
from 01:00 PM to 02:00 PM
Where CRUK CI Lecture Theatre
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Yardena Samuels; Weizmann Institute, Israel. 

24th GI Cancer Forum

When Mar 09, 2016
from 05:30 PM to 07:30 PM
Where CRUK-CI lecture theatre
Contact Name
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Speakers include: 

Prof George Hanna, Imperial College London.

'Diagnostics and molecular drivers of volatile biomarkers in oesophageal adenocarcinoma.'

 

Mr Simon Buczaki, CRUK, Cambridge.

'Toenails to tumours - targeting cellular quiescence in colorectal cancer.'

 

Dr Maria Secrier and Dr Nadeera de Silva, MRC Cancer Unit, Cambridge. 

'Mutational signatures reveal subgroups of distinct aetiology and new therapeutic opportunities in oesophageal adenocarcinoma.'

 

Tea will be provided at 5.30pm and there will be a drinks and nibbles reception from 7.30pm. 

All with an interest in cancer are welcome to attend!

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25th GI Cancer Forum

When Jul 13, 2016
from 05:30 PM to 07:30 PM
Where CRUK-CI lecture theatre, Cambridge Biomedical Campus
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5.30pm: Tea and Coffee

Prof George Hanna, Imperial College, London. 'Diagnostics and molecular drivers of volatile biomarkers in
oesophageal adenocarcinoma'

Mr Simon Buczacki, CRUK, Cambridge. 'Toenails to tumours – targeting cellular quiescence in
colorectal cancer'

Dr Maria Secrier, CRUK, Cambridge. 'Update on the Oesophageal International Cancer Genome Consortium Project'

Prof Rebecca Fitzgerald, MRC Cancer Unit. 'The next 25 GI Cancer Forums'

7.30pm: Drinks and Nibbles Reception

All with an interest in cancer are very welcome to attend!

‘Combine and conquer: critical pre-clinical and clinical aspects of targeted anti-cancer drugs’

When Dec 08, 2015
from 12:00 PM to 01:00 PM
Where CRUK CI Lecture Theatre
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Dr Udai Banerji, Drug Development Unit ICR.

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Cambridge Advanced Imaging Series: Live Cell Biochemistry by Night

When Feb 19, 2016
from 03:00 PM to 04:00 PM
Where CRUK-CI lecture theatre
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Speaker: Dr Alessandro Esposito, MRC Cancer Unit

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Cambridge Cancer Centre Early Detection Programme launch event

When Jan 18, 2016
from 03:00 PM to 06:30 PM
Where CRUK Cambridge Institute Lecture Theatre - Robinson Way Cambridge CB2 0RE
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Cambridge Cancer Centre Early Detection Programme launch event.

http://www.eventbrite.com/e/cambridge-cancer-centre-early-detection-programme-launch-tickets-19040002159.

For further information e-mail: cja52@cam.ac.uk

Cambridge Science Festival 2017

When Mar 13, 2017 12:00 AM to
Mar 27, 2017 12:00 AM
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CCC Early Detection Special Lecture Series

Early Detection Special Lecture Series
When Nov 30, 2015
from 01:00 PM to 05:15 PM
Where CRUK Cambridge Institute
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13.00 Josep V. Forment, PhD. The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge.

CRUK Cambridge Institute lecture theatre

Title: Forward genetic screens in haploid mammalian stem cells: looking beyond CRISPR/Cas9

 

14.00 Daniel Muñoz-Espín, PhD. Spanish National Cancer Research Center, Madrid

CRUK Cambridge Institute lecture theatre

Title: Cellular senescence, plasticity and cancer: new frontiers and novel tools for diagnosis and therapy


15.15 Emma Rawlins, PhD. The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge

CRUK Cambridge Institute lecture theatre           

Title: Escaping homeostasis in the airway epithelium

 

16.15 Ines de Santiago, PhD. Cancer Research UK, Cambridge Institute

CRUK Cambridge Institute lecture theatre

Title: A systems genetics analysis to elucidate mechanisms underlying cancer susceptibility and initiation

CCC Early Detection Special Lecture Series

Early Detection Special Lecture Series
When Dec 01, 2015
from 01:00 PM to 03:00 PM
Where CRUK Cambridge Institute
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13.00 Olga Anczukow, PhD. Cold Spring Harbor Laboratory, NY

CRUK Cambridge Institute room 009

Title: Alternative-splicing alterations in breast cancer: molecular and therapeutic insights from model systems

 

14.00 Marcin Iwanicki, PhD. Joan S. Brugge lab, Department of Cell Biology, Harvard Medical School

CRUK Cambridge Institute room 009

Title: Modeling ovarian carcinoma initiation: New insights into mutant p53 activities in the cell-of-origin of high-grade ovarian cancer

 

Crick 2016 Lecture

When Feb 17, 2016
from 11:00 AM to 12:00 PM
Where Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology
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CRUK CI Annual Symposium

When Mar 04, 2016 09:00 AM to
Mar 05, 2016 05:00 PM
Where CRUK CI Lecture Theatre
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The full programme will be published shortly before the Symposium, but our currently confirmed speakers include:

Tissue architecture: imaging and bioengineering

  • Mikala Egeblad (Cold Spring Harbor Laboratory)
  • Alison McGuigan (University of Toronto)
  • Lucas Pelkmans (University of Zurich)
  • Itai Yanai (Technion University)

Approaches to understanding tumours at cellular resolution

  • James Eberwine (University of Pennsylvania)
  • Je H. Lee (Cold Spring Harbor Laboratory)
  • Alex Van Oudenaarden (Hubrecht Institute)
  • Rahul Satija (New York University)

3D analysis of transcriptional and mutational profiles

  • Peter Campbell (Wellcome Trust Sanger Institute)
  • William Greenleaf (Stanford University)
  • James Hicks (Cold Sping Harbor Laboratory)
  • Ehud Shapiro (Weizmann Institute)

Functional phenotypic diversification of tumour cells

  • L. Stirling Churchman (Harvard University)
  • Christina Curtis (Stanford University)
  • Caroline Dive (CRUK Manchester Institute)

Registration

You can register online to attend the symposium. The deadline for registering and submitting an abstract is 5pm on 21 January 2016. Registration (with no abstract submission) will remain open until 18 February 2016 or until all places are taken. Spaces are limited, so early registration is advised.

Full registration (£250) includes lunch and dinner on Friday 4 March, lunch and the symposium dinner (7.00pm for 7.30pm in Westminster College, Cambridge) on Saturday 5 March. For delegates who do not wish to attend the symposium dinner, symposium only registration is available (£200); this includes lunch and dinner on Friday 4 March and lunch on Saturday 5. Registration fees will be covered for members of the Cambridge Cancer Centre.

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CRUK-CI Seminars in Cancer

When Mar 22, 2016
from 01:00 PM to 02:00 PM
Where CRUK-CI lecture theatre
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Speaker: Scott Lowe, Memorial Sloan Kettering Cancer Centre, New York, USA.

CRUK-CI Seminars in Cancer: Proteomics in Cell Signalling and Cancer Research

When Jan 21, 2016
from 01:00 PM to 02:00 PM
Where CRUK CI Lecture Theatre
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Speaker: Matthias Mann, Max-Planck Institute of Biochemistry, Munich, and Novo Nordisk Foundation Center for Protein Research, Copenhagen.

CSAR: The Challenge and Excitement of Discovering New Medicines

When Jan 18, 2016
from 07:30 PM to 09:00 PM
Where Churchhill College, Wolfson Lecture Theatre, Storeys Way, CB3 0DS.
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Cambridge Society for the Application of Research (CSAR)

Speaker: Dr Menelas Pangalos, Executive Vice-President, Astra Zeneca.

Early Detection Forum lecture: The dynamics of clonal evolution

When Jun 13, 2016
from 10:00 AM to 11:00 AM
Where CRUK-CI lecture theatre
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Speaker: Jamie Blundell, PhD, Levy Lab, Laufer Center for Physical and Quantitative Biology, Stony Brook University, USA.

Dr Blundell's work combines experimental evolution, analyses of “big data” sets obtained from genetic lineage-tracking tools, and theory to understand how quickly clonal populations evolve. The central idea is to develop a quantitative understanding of clonal evolution in order to (i) predict how cellular populations evolve in the lab (ii) make more informed treatment decisions of evolutionary diseases in the clinic.

 

 

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Early Detection Forum Lecture. Early cancer detection: lessons of the past decade

When Apr 21, 2016
from 11:30 AM to 12:30 PM
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Speaker: Don Listwin, Founder and Chairman of the Canary Foundation*, Palo Alto, California, USA

Don is a 25-year veteran of the technology industry - he was CEO of Sana Security, Openwave and the #2 executive at Cisco Systems.

We expect this to be a popular lecture. To ensure your seat please sign up at http://www.eventbrite.com/e/early-detection-forum-lecture-early-cancer-detection-lessons-of-the-past-decade-tickets-23790659503

*Canary Foundation, the US’ only non-profit organization devoted exclusively to early detection of cancer, when it is most treatable and chances for full recovery are greatest.

Canary Foundation has assembled teams of cancer researchers recognized by their peers as leaders in their disciplines from across multiple institutions to attack the problem of early detection in a new, collaborative, action-oriented manner with the foremost objective of translating research into clinical applications. 

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Early Detection Forum Lecture. Making NanoMedicine Personal: Translating Genome-Wide Information & Point of Care Diagnostics into the Clinic.

When Jun 17, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI Lecture Theatre
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Speaker: Professor Matt Trau

The University of Queensland,

Centre for Personalised NanoMedicine,

Australian Institute for Bioengineering and Nanotechnology (AIBN),

School of Chemistry and Molecular Biosciences,

Brisbane QLD 4072, Australia.

 

Web:  aibn.uq.edu.au/matt-trau

 

Talk will be followed by refreshments and informal networking.

For catering purposes click here to sign up

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Abstract

Modern medicine is currently transitioning to a new paradigm of precision and personalized care, where patients will be comprehensively screened and monitored for the detailed molecular abnormalities that characterise their specific disease.  In the past decade, nanotechnology has provided new tools (e.g., next-generation sequencing) with unprecedented power to comprehensively interrogate genetic, transcriptomic and epigenetic information.  The Centre for Personalised Nanomedicine at UQ is focused on translating these new technologies into a clinical setting, whilst simultaneously developing the next generation of point-of-care diagnostic technologies to further empower the personalised and precision medicine approach.  As part of a major National Collaborative grant funded by the National Breast Cancer Foundation (“Enabling clinical epigenetic diagnostics: The next generation of personalized breast cancer care”, CG-12-07), our consortium recently published hundreds of epigenetic regions that area highly informative in cancer1-2.  These are now being validated in a real-time clinical setting, where comprehensive DNA, methyl-DNA and RNA information is collected in tandem and analysed.  In this paper we will present data on the clinical translation of this approach, highlighting some of the positive impacts that such an approach can make on the “recovery trajectory” of cancer patients.  Along with comprehensive DNA/RNA/methylated-DNA sequencing methodologies, several point-of-care nanotechnologies recently developed by our lab will be presented3-12. These include novel technologies for detecting circulating free DNA/RNA/methyl-DNA, circulated tumour cells, exosomes and protein biomarkers.  Several of these technologies have been developed collaboratively with US partners via a collaborative NIH grant (“Accelerated Molecular Probe Pipeline”, U01AI082186-01).    

 

References

1)       Stone, et al.,  Nature Communications (2015)

2)       Stirzaker, et al.,  Nature Communications (2015)

3)       Wee, Trau, Nature Chemistry (2014)

4)       Wang, Wee, Trau, Chem Comm. (2015)

5)       Wang, Vaidyanathan, Shiddiky; Trau, ACS Nano (2015).

6)       Vaidyanathan, van Leeuwen, Rauf, Shiddiky, Trau,  Sci Reports (2015)

7)       Grewal, Shiddiky, Spadafora, Cangelosi, Trau, J. Phys. Chem. C (2015)

8)       Wee, Sakandar, Shiddiky, Dobrovic, Trau  Clinical Chem. (2015)

9)       Korbie, Lin, Wall, Nair, Stirzaker, Clark, Trau, Clinical Epigenetics (2015)

10)   Wee, Lau, Botella, Trau, Chem Comm (2015)

11)   Lane, Korbie, Anderson, Vaidyanathan, Trau, Sci Reports (2015)

12)   Anderson, Lane, Korbie, Trau, Langmuir (2015)


 

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Festival of Ideas: Is earlier necessarily better?

When Oct 24, 2016
from 05:00 PM to 06:30 PM
Where McCrum Lecture Theatre, Bene't Street, Cambridge
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Is earlier necessarily better?

We invite you to explore the societal, ethical, legal and economic issues surrounding earlier cancer detection. Using excerpts from the BBC Horizon programme, an invited panel of experts will debate the issue with the audience. 


 

 

 

 

GIPA Seminar Series: Gene Transfer Technologies and New Gene Therapy Strategies

Speaker: Prof. Luigi Naldini, Director of the San Raffaele Telethon Institute for Gene Therapy, Milan (Italy)
When Jan 19, 2016
from 11:30 AM to 12:30 PM
Where Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.
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Prof. Naldini described for the first time the use of lentiviral vectors for gene transfer into non-dividing cells in 1996. He is a leading scientist in the field of gene therapy with the final goal of therapeutic translation. The team led by Prof. Naldini has achieved amazing results by performing gene correction in the hematopoietic system, including cure or significant improvement of patients affected by leukodystrophy and Wiskott-Aldrich syndrome.

 

After the talk there will be a buffet lunch (from 1:30 to 2:30pm) for the speaker and PhDs / postdocs. Please come along and take the opportunity to talk to Prof. Naldini!

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Hutchison/MRC Research Centre Annual Retreat

When Nov 20, 2015
from 09:00 AM to 05:30 PM
Where Granta Centre, Grant Park, Great Abington, Cambridge
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Hutchison/MRC Research Centre Annual Retreat

Granta Centre, Grant Park, Great Abington, Cambridge.

09:00-17.30

Hutchison/MRC Research Centre Annual Retreat 2016

When Dec 02, 2016
from 09:00 AM to 06:00 PM
Where Møller Centre
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Lectures in Cancer Biology Symposium - Unanswered Questions: Tumours at Cellular Resolution

Lectures in Cancer Biology: Focusing on Cancer Sites
When Mar 04, 2016 12:00 AM to
Mar 05, 2016 12:00 AM
Where CRUK-CI lecture theatre
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Lectures in Cancer Biology: Brain Cancer

Lectures in Cancer Biology: Focusing on Cancer Sites
When Feb 18, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI lecture theatre
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Speaker: Prof. Richard Gilbertson

Lectures in Cancer Biology: Leukaemia

Lectures in Cancer Biology: Focusing on Cancer Sites
When Feb 04, 2016
from 09:30 PM to 10:30 PM
Where CRUK-CI lecture theatre
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Speaker: Brian Huntley

Lectures in Cancer Biology: Common germline genetic variation and risk of cancer

When Jun 16, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI lecture theatre
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Speaker: Prof Paul Pharaoh, Dept of Oncology, University of Cambridge

Lectures in Cancer Biology: Breast Cancer

Lectures in Cancer Biology: Focusing on Cancer Sites
When Mar 17, 2016
from 09:30 AM to 10:30 AM
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Speaker: Prof. Carlos Caldas

Lectures in Cancer Biology: Prostate Cancer

Lectures in Cancer Biology: Focusing on Cancer Sites
When Mar 10, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI lecture theatre
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Speaker: Dr. Vincent Gnanapragasam

Lectures in Cancer Biology: Surgery and prostate cancer

When Jun 02, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI lecture theatre
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Speaker: Mr Adam Nelson, CRUK-CI and Cambridge University Hospitals

Lectures in Cancer Biology: Oesophageal Cancer

Lectures in Cancer Biology: Focusing on Cancer Sites
When Jan 21, 2016
from 09:30 PM to 10:30 PM
Where CRUK-CI lecture theatre
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Speaker: Prof. Rebecca Fitzgerald

Lectures in Cancer Biology: Ovarian cancer

Lectures in Cancer Biology: Focusing on Cancer Sites
When Feb 11, 2016
from 09:30 AM to 10:30 AM
Where CRUK-CI lecture theatre
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Speaker: James Brenton

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