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AV2

AURORA-A over-expression, which occurs in 30-50% of common cancers, over-rides the mitotic spindle assembly checkpoint mediated by MAD2, allowing anaphase entry with lagging chromosomes. Aurora-A over-expressing cells (right) or control cells (left) in prometaphase (top) or anaphase (bottom). DNA is stained red and MAD2, green.
AV2
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