The MRC Cancer Unit is a purpose-built cancer research facility. We have access to a wide-range of equipment to suit our research needs, here are just a few examples.
Our researchers enjoy access to equipment for confocal (Zeiss LSM 880 Airyscan confocal with FCS capabilities to enable the study of molecular interactions), live cell, and high content screening microscopy, as well as biophysical imaging (optogenetics, multiphoton microscope), and histopathology (Bond IHC staining system).
The Seahorse extracellular flux analyser allows researchers to investigate mitochondrial respiration and glycolysis, while a liquid chromatography-mass spectrometry (LCMS) machine was acquired in 2012 for quantitative, small molecule metabolite analysis. A mass spectrometry suite is currently in development.
An Xstrahl X-ray irradiator delivers precise doses of ionizing radiation to in vitro samples to study the effect of damage to the cell’s DNA. We also have a joint (with CIMR) cell sorting and flow cytometry facility (headed by Dr. Reiner Schulte). The facility is capable of performing cell sorting for researchers to isolate cell populations needed for further studies.
To support the advanced computational approaches used in the MRC Cancer Unit, we host a dedicated 16 node high performance computing (HPC) cluster.
Additional scientific support services (media preparation, mycoplasma testing) are provided by a dedicated Laboratory Management team who manage core facilities and provide support in areas such as equipment and health and safety. Our researchers also have access to dedicated IT service as well as a modern canteen and meeting rooms, which are frequently used for informal scientific and social events.